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Sleep

Wake Up to Your Genetic Potential

These reports provide valuable insights into your genetic predispositions related to sleep-related issues and disorders, such as being a night owl, having a certain sleep duration, or the risk of fragmented sleep, narcolepsy, and the impact of stress or caffeine on sleep quality.

Caffeine Affecting sleep

Stress Affecting Sleep

Narcolepsy Risk

Fragmented Sleep Risk

Sleep Duration

Night Owl Likelihood

Reports

Caffeine Affecting sleep

Genes of Interest: ADORA2A, CYP1A2

The genes ADORA2A and CYP1A2 play a role in how an individual may respond to caffeine. These genes are involved in the metabolism and breakdown of caffeine in the body. Variations in these genes can affect the rate at which caffeine is broken down, leading to differences in caffeine sensitivity and sleep risk.

ADORA2A is a gene that codes for the adenosine A2A receptor, which is involved in the regulation of the wake-sleep cycle. Variations in the ADORA2A gene can affect the way caffeine interacts with this receptor, leading to differences in caffeine sensitivity.

CYP1A2 is a gene that codes for the CYP1A2 enzyme, which is responsible for the metabolism of caffeine. Variations in the CYP1A2 gene can affect the rate at which caffeine is broken down, leading to differences in caffeine sensitivity and sleep risk.

Fragmented Sleep Risk

Genes of Interest: FABP7

FABP7, also known as B-FABP, is a gene that has been shown to play a role in fragmented sleep risk. Studies have shown that variations in the FABP7 gene may affect the regulation of sleep and circadian rhythm, leading to an increased risk of fragmented sleep.

One study found that individuals with a specific variant of the FABP7 gene had a higher risk of fragmented sleep compared to those without the variant. This variant was associated with a decrease in the expression of FABP7 in the brain, leading to changes in the regulation of sleep and circadian rhythm.

Another study showed that individuals with a variation in the FABP7 gene had a higher risk of sleep disturbances and poor sleep quality compared to those without the variation. This finding suggests that the FABP7 gene may play a role in regulating the quality and duration of sleep.

Narcolepsy Risk

Genes of Interest: CPT1B, TCRA, P2RY11, HCRT

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and sudden loss of muscle tone, called cataplexy. While the exact cause of narcolepsy is not yet known, genetic factors may play a role in increasing a person's risk of developing the condition. Studies have shown that certain genes, including CPT1B, TCRA, P2RY11, and HCRT, may be associated with an increased risk of narcolepsy.

CPT1B is a gene that encodes a protein called carnitine palmitoyltransferase 1B, which is involved in the metabolism of fats in the body. A study conducted in 2009 found that individuals with a specific variant of the CPT1B gene had an increased risk of developing narcolepsy.

TCRA is a gene that provides instructions for making a protein called the T-cell receptor alpha chain, which is involved in the immune system's response to foreign substances. A study conducted in 2010 found that individuals with certain variants of the TCRA gene had an increased risk of developing narcolepsy.

P2RY11 is a gene that provides instructions for making a protein called purinergic receptor P2Y11, which is involved in the regulation of the immune system. A study conducted in 2012 found that individuals with certain variants of the P2RY11 gene had an increased risk of developing narcolepsy.

HCRT is a gene that provides instructions for making a protein called hypocretin, which regulates the sleep-wake cycle and appetite. A study conducted in 2009 found that individuals with certain variants of the HCRT gene had an increased risk of developing narcolepsy.

Night Owl Likelihood

Genes of Interest: AANAT, CRY1, PER3

Your genes can influence your sleep patterns, including whether you are a night owl or a morning person. The genes AANAT, CRY1, and PER3 have been identified as playing a role in regulating the circadian rhythm, which is your body's internal clock that helps regulate when you feel awake and when you feel tired.

AANAT, or the arylalkylamine N-acetyltransferase gene, helps regulate the production of melatonin, a hormone that helps regulate your sleep-wake cycle. CRY1, or the cryptochrome 1 gene, helps regulate the circadian rhythm by functioning as a core component of the molecular clock that sets the timing of daily rhythms. PER3, or the period 3 gene, helps regulate the circadian rhythm by encoding a component of the molecular clock.

Sleep Duration

Genes of Interest: ABCC9, FABP7, ARNTL, CLOCK

The genes ABCC9, FABP7, ARNTL, and CLOCK have been shown to have an impact on sleep duration. ABCC9, also known as the sulfonylurea receptor gene, has been linked to regulating sleep-wake cycles and affecting the duration of sleep. A study found that variations in the ABCC9 gene were associated with shorter sleep duration in older adults.

FABP7, also known as heart-type fatty acid-binding protein 7, has been shown to play a role in regulating sleep patterns. A study found that individuals with high levels of FABP7 had a shorter sleep duration compared to those with low levels.

The gene ARNTL, also known as the BMAL1 gene, has been linked to regulating circadian rhythms and sleep patterns. A study found that individuals with certain variations in the ARNTL gene had a shorter sleep duration compared to those without these variations.

The CLOCK gene has also been shown to play a role in regulating circadian rhythms and sleep patterns. A study found that variations in the CLOCK gene were associated with shorter sleep duration in individuals with depression.

Stress Affecting Sleep

Genes of Interest: COMT, DTNBP1, CHRNA4, BDNF

Genes play a role in how individuals respond to stress and how it affects their sleep. The genes COMT, DTNBP1, CHRNA4, and BDNF are all associated with stress and its impact on sleep.

COMT, also known as catechol-O-methyltransferase, is involved in the breakdown of neurotransmitters such as dopamine and norepinephrine. Variations in the COMT gene can affect an individual's ability to cope with stress, leading to sleep problems.

DTNBP1, also known as dysbindin, is involved in the regulation of neurotransmitter release and synaptic function. Changes in the DTNBP1 gene have been linked to stress and sleep disturbances.

CHRNA4, a gene that codes for a subunit of the nicotinic acetylcholine receptor, is also involved in stress and sleep regulation. Variations in this gene can lead to altered neurotransmitter signaling and sleep problems.

BDNF, or brain-derived neurotrophic factor, is a protein that supports the survival and growth of neurons. Changes in the BDNF gene have been linked to stress and sleep disturbances, as well as other psychiatric disorders.

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