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Eye Health

See Your Way to Better Eye Health

Your eyes are the windows to your soul, and the eye health reports generated by Kokora DNA health tests can help you keep them healthy and clear. These reports provide valuable insights into your genetic predisposition to eye conditions such as age-related macular degeneration, cataracts, or glaucoma, as well as your ability to convert beta-carotene and potential deficiencies in B vitamins. Armed with this information, you can take proactive steps to maintain healthy vision.

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B-Vitamin Deficiency and Eye Health

Beta-Carotene Conversion

Open-Angle Glaucoma Risk

Cataracts Risk

Sight Degeneration With Age

Reports

B-Vitamin Deficiency and Eye Health

Genes of Interest: NBPF3, MTHFR, SLC19A1

The genes NBPF3, MTHFR, and SLC19A1 play a crucial role in regulating our levels of B vitamins, which are essential for overall health and well-being, including eye health. B vitamins are involved in a range of processes in the body, including DNA synthesis, energy production, and the maintenance of a healthy nervous system.

Studies have shown that variations in the NBPF3 gene can impact the levels of vitamin B6 in the body. Vitamin B6 is involved in the formation of the neurotransmitter serotonin, which helps regulate mood, and is also involved in the production of red blood cells.

The MTHFR gene is involved in the metabolism of folate, also known as vitamin B9. Folate plays a crucial role in DNA synthesis and the prevention of birth defects. Variations in the MTHFR gene have been linked to an increased risk of folate deficiency, which can lead to a range of health problems.

The SLC19A1 gene is involved in the transport of vitamin B12 into cells, where it is needed for DNA synthesis and the formation of red blood cells. Vitamin B12 deficiency can lead to a range of health problems, including anemia and nerve damage.

In conclusion, the genes NBPF3, MTHFR, and SLC19A1 play an important role in regulating our levels of B vitamins and therefore have a significant impact on our overall health and well-being, including eye health.

Beta-Carotene Conversion

Genes of Interest: BCO1

The gene BCO1 plays an important role in the conversion of beta-carotene into retinol, a form of vitamin A that is essential for good eye health. Studies have shown that variations in the BCO1 gene can impact the efficiency of this conversion, leading to a reduced ability to produce retinol from beta-carotene.

One study published in the journal "Nutrition" found that individuals with a specific variation of the BCO1 gene were less efficient at converting beta-carotene into retinol, which could result in a higher risk of vitamin A deficiency and related eye problems.

Another study published in the "American Journal of Clinical Nutrition" found that individuals with a certain variation of the BCO1 gene were less efficient at converting beta-carotene into retinol, which could impact their eye health over time.

These findings highlight the importance of considering genetic factors when it comes to maintaining good eye health, and the role that the BCO1 gene plays in the conversion of beta-carotene into retinol.

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Cataracts Risk

Genes of Interest: EPHA2

Cataracts are a common eye condition that can cause vision loss and eventually lead to blindness. While aging is a major risk factor for cataracts, genetics can also play a role in the development of this condition. One gene of interest in this area is EPHA2.

Studies have shown that variations in the EPHA2 gene can impact the risk of developing cataracts. For example, a study published in the journal "Human Genetics" found that certain variants of the EPHA2 gene were associated with an increased risk of cataracts in a Chinese population.

Another study published in the "Journal of Human Genetics" found that individuals with specific EPHA2 gene variants were more likely to develop cataracts at a younger age compared to those without these variants.

These findings suggest that the EPHA2 gene may play a role in the development of cataracts, and that individuals with specific variants of this gene may be at an increased risk for this condition.

Open-Angle Glaucoma Risk

Genes of Interest: MYOC, LOXL1

Genetic factors play a significant role in determining a person's risk for developing open-angle glaucoma, a common form of eye disease that can lead to vision loss. Two genes of interest in open-angle glaucoma are MYOC and LOXL1.

Studies have shown that variations in the MYOC gene can impact the amount of a protein called myocilin produced in the eye. Elevated levels of myocilin have been linked to an increased risk of developing open-angle glaucoma.

Variations in the LOXL1 gene have also been associated with an increased risk of developing open-angle glaucoma. The LOXL1 gene provides instructions for making an enzyme that helps to maintain the shape and stability of the delicate meshwork in the eye that drains fluid. Variations in this gene may contribute to the abnormal buildup of pressure in the eye that is a hallmark of open-angle glaucoma.

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Sight Degeneration With Age

Genes of Interest: HTRA1, CFH, C3, TLR3

HTRA1, which is involved in the regulation of the extracellular matrix, has been linked to age-related macular degeneration (AMD) in multiple studies. Variations in the HTRA1 gene have been associated with a higher risk of developing AMD, the most common cause of vision loss in people over the age of 50.

CFH, a gene involved in the regulation of the immune system, has also been linked to AMD risk. Studies have shown that variations in the CFH gene can increase the risk of developing AMD, particularly in smokers.

C3, a gene involved in the regulation of the complement system, has also been linked to the risk of AMD. Studies have shown that variations in the C3 gene can lead to a higher risk of developing AMD, especially in individuals with a family history of the condition.

TLR3, a gene involved in the regulation of the immune system, has also been linked to the risk of developing AMD. Studies have shown that variations in the TLR3 gene can increase the risk of developing the condition, particularly in individuals with a family history of AMD.

By understanding the genetic basis of sight degeneration with age, individuals can gain insight into their risk and take steps to protect their vision.

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